April 20, 2024

The prototype of a silicon device that transforms skin tissue into blood vessels or nerve cells has been standardized. This means it is now possible to make it consistent and reproducible. This work was done by researchers from the Indiana University School of Medicine and brought the device closer to being used as a treatment for people suffering from various health issues.

Tissue nano transfection is a non-invasive technology reprograms tissue function using an electric spark. This allows for specific genes to be delivered in fractions of seconds. The device could convert skin tissue into blood vessels in laboratory experiments. This allowed the device to be used to treat a severely injured leg. This technology can reprogram tissue in different therapies, such as treating stroke-related brain damage or preventing nerve damage from occurring due to diabetes.

Chandan Sen, director of Indiana Center for Regenerative Medicine and Engineering, associate vice president for Research, and Distinguished Professor at IU School of Medicine stated that “this report on how to produce these tissue nano transfection chips precisely will enable other researchers in this new development of regenerative medicine.”

Sen is also the leader of the IU Precision Health Initiative’s engineering and regenerative medicine scientific pillars and the lead author for the new publication.

He said that the tiny silicon chip allows nanotechnology to alter the function of living parts. “For example, if someone has damaged blood vessels due to a traffic accident and requires blood supply, then we cannot rely on the existing blood vessel because it is crushed. But we can convert skin tissue into blood vessels and rescue the limb in danger.

Researchers published engineering details on how the chip was manufactured in the Nature Protocols Report.

Sen stated that this manufacturing information would allow for further development of the chip in the hope that it can be used in clinical settings in many places around the globe.

He said, “This is about engineering and manufacturing the chip.” “The nanofabrication of a chip takes about five to six days. Anyone can do it with the help of this report.

Sen stated that he hopes to get FDA approval for the chip in less than a year. The FDA approval will allow the device to be used in clinical Research, such as for patients in hospitals, emergency rooms, and health centers, as well as in other emergencies by first responders or military personnel.

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